Metatron Hunter 4025 Has Been Used For More Skin Diseases
Metatron Hunter 4025 has axial resolution of 30 µm. Application of this device allows to study epidermis on cellular and sub-cellular levels.
Nowadays objectives and limits of three-dimensional NLS-ultramicroscanning research in dermatology have become very broad.
The following has become real:
- evaluation of treatment efficiency of diseases characterized by skin sclerosis (localized scleroderma, generalized scleroderma), edematous (lipo-dermatosclerosis) and chronic inflammatory (psoriasis) dermatosis;
- measuring skin tumors invasion extent and monitoring after surgical interventions, cryo- and laser therapy at melanotic cancer, basal-like cancer, hemangioma, fibroma, seborrheic keratosis;
- study of local and system medications’ effect to skin (corticosteroids, estradiol).
In accordance with a methodology the NLS-ultramicroscanning diagnostics of skin diseases must be carried out by comparing of affected area with healthy skin at counterlateral homological area.
At NLS-graphy with use of non-linear sensors of 4.9 GHz frequency, normal skin is represented by three layers: epidermis, derma and subcutaneous tissue. Regional and age-related peculiarities of skin thickness are conditioned by derma thickness mainly, which depends in the first place on collagen content in it.
It is considered that at NLS-study with sensor frequency of 1.4 GHz, normal epidermis is visualized poorly, because real thickness of epidermis is 0.02 – 0.5 mm, which is a limit of resolution for system of this class.
Epidermis is a moderately chromogenic structure (2-3 points at Fleindler’s scale), chromogeneity of which depends on thickness and desquamation rate of horny layer.
Super-high-frequency non-linear sensors allow to research more superficial papillary layer and underlying reticular layer of derma, The latter is characterized by more homogeneous structure.
For differential diagnostics of such skin tumors as hemangioma or melanoma, modes of ultramicroscanning together with spectral-entropic analysis (SEA) may be successfully applied.