Biophilia Intruder and Bronchial Asthma

Bronchial asthma is a heterogeneous disease characterized by chronic airway inflammation involving a variety of cells (such as eosinophils, mast cells, T lymphocytes, neutrophils, airway epithelial cells, etc.) and cellular components. This chronic inflammation is associated with airway hyperresponsiveness, often with widespread and variable reversible expiratory airflow limitation, resulting in recurrent episodes of wheezing, shortness of breath, chest tightness, and/or coughing that vary in intensity over time. Most of the onset and exacerbation occur at night and/or early in the morning, and most patients can be relieved by themselves or after treatment. If the diagnosis and treatment of bronchial asthma is not timely, the airway can be irreversibly narrowed and remodeled with the prolongation of the course of the disease.

In daily life, preparing a set of Biophilia Intruder equipment for your family and yourself is equivalent to having a resident family doctor at home, who can not only pay attention to our own health status, but also maintain our health in daily life.

Cause

1. Genetic factors

Individual allergies and the influence of the external environment are risk factors for the disease. Asthma is related to polygenic inheritance. The prevalence of relatives of asthma patients is higher than that of the group, and the closer the kinship is, the higher the prevalence; the more severe the patient's condition, the higher the prevalence of relatives.

2. Allergens

(1) Indoor and outdoor allergens Dust mites are the most common and most harmful indoor allergens, and are an important cause of asthma worldwide. Dust mites exist in secretions such as fur, saliva, urine and feces. Fungus is also one of the allergens present in indoor air, especially in dark, humid and poorly ventilated places. Common outdoor allergens: Pollen and grass powder are the most common outdoor allergens that cause asthma attacks, and other specific and non-specific inhalants such as animal dander, sulfur dioxide, and ammonia.

(2) Common allergens of occupational allergens include grain meal, flour, wood, feed, tea, coffee beans, silkworm, pigeon, mushroom, antibiotics (penicillin, cephalosporin), rosin, reactive dyes, persulfuric acid salts, ethylenediamine, etc.

(3) Drugs and food Aspirin, propranolol (propranolol) and some non-corticosteroid anti-inflammatory drugs are the main allergens of drug-induced asthma. In addition, fish, shrimp, crab, eggs, milk and other foods can also induce asthma.

3. Triggering factors

Common air pollution, smoking, respiratory infections such as bacteria, viruses, protozoa, parasites and other infections, pregnancy, strenuous exercise, climate change; various non-specific stimuli such as inhalation of cold air, distilled water droplets, etc. can induce asthma attacks. In addition, mental factors can also induce asthma.

clinical manifestations

Paroxysmal expiratory dyspnea with wheezing or paroxysmal cough, chest tightness. Severe cases are forced to take a sitting position or orthopnea, dry cough or cough a lot of white foamy sputum, and even cyanosis. Sometimes cough is the only symptom (cough variant asthma). Some adolescent patients have chest tightness, cough and dyspnea as the only clinical manifestations during exercise (exercise asthma). Asthma symptoms can start within minutes and resolve over hours to days with bronchodilators or on their own. Some patients experience relapse after a few hours of remission. Nocturnal and early morning attacks and exacerbations are often a feature of asthma.

treat

At present, there is no effective treatment method, but insisting on long-term standardized treatment can well control asthma symptoms, reduce recurrence or even no longer attack.

1. Treatment goals

(1) Complete control of symptoms;

(2) To prevent the onset or exacerbation of the disease;

(3) The lung function is close to the individual optimal value;

(4) Normal activity;

(5) Improve self-awareness and ability to deal with acute exacerbations, and reduce the chance of emergency or hospitalization;

(6) Avoid adverse drug reactions;

(7) Prevent irreversible airway obstruction;

(8) Prevent death from asthma.

2. Basic clinical strategies for asthma prevention and treatment

(1) Long-term anti-inflammatory treatment is the basic treatment, and inhaled corticosteroids are the first choice. Commonly used inhaled drugs are beclomethasone (BDP), budesonide (budesonide), fluticasone (fluticasone), mometasone (momethasone), etc., the latter two have stronger biological activity and longer-lasting effects. It usually takes more than a week of regular inhalation to take effect.

(2) The drug of choice for emergency relief of symptoms is an inhaled β2 agonist. β2 agonists mainly activate the β2 receptors in the respiratory tract, activate adenylyl cyclase, increase the intracellular cyclic adenosine monophosphate (cAMP) content, and reduce free Ca, thereby relaxing the bronchial smooth muscle. It is the first choice for controlling acute asthma attacks. drug.

(3) If the disease control is not satisfactory after regular inhalation of hormones, it is advisable to add inhaled long-acting β2 agonists, or sustained-release theophylline, or leukotriene modifiers (combination medication); also consider increasing the amount of inhaled hormones.

(4) Intensive treatment may be considered for patients with severe asthma who have long-term recurrent attacks after the above treatment. That is, according to the treatment of severe asthma attack, high-dose hormones and other treatments are given, and the dose of hormones is gradually reduced after 2 to 4 days after the symptoms are completely controlled, the pulmonary function returns to the optimal level, and the PEF fluctuation rate is normal. Some patients achieved satisfactory disease control after intensive treatment.

3. Comprehensive treatment measures

(1) Eliminate the cause and cause.

(2) Prevention and treatment of co-existing diseases, such as allergic rhinitis, reflux esophagitis, etc.

(3) Immunomodulatory therapy.

(4) Regularly check whether inhaled drugs are used correctly and compliance with doctor's orders.

Using Biophilia Intruder equipment, we can not only improve the immunity and resistance of us and our family, but also prevent various diseases and make us more and more healthy.